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They inhibit both COX-1 (associated with GI protection) and COX-2 (associated with inflammation)

8 Weight Loss and GLP-1RA Therapy The use of all types of GLP-1RAs, to a greater or lesser extent, leads to body weight reduction due to decreased appetite and promoting feelings of satiety and stomach fullness, resulting in a lower calorie intake from food

Common side effects Urinary tract infection (UTI) Vaginal yeast infection (females) Upper respiratory tract infection Increased cholesterol or triglycerides Increased urination Other mild side effects Nausea Genital yeast infection (males) Joint pain Increased thirst Weight loss Serious side effects Diabetic ketoacidosis (DKA): nausea, vomiting, abdominal pain, fatigue, increased thirst, dry mouth, fruity breath, breathing difficulty Dehydration/hypotension: dizziness, lightheadedness, reduced urine output Hypoglycemia (with insulin or sulfonylureas): anxiety, shakiness, confusion, fatigue, hunger, rapid heartbeat Severe kidney infections (pyelonephritis, urosepsis): fever, chills, back pain, painful urination Necrotizing fasciitis (Fourniers gangrene): severe genital/perineal pain, swelling, redness Amputations (rare): new foot/leg sores, ulcers, infections Allergic reactions: hives, rash, facial/lip/tongue swelling, breathing difficulty Pancreatitis: upper abdominal pain radiating to back, fever, nausea, vomiting Who should not take Jardiance

In rodents, this behavior can be studied in the operant self-administration model (Sanchis-Segura and Spanagel, 2006)

E., & Jordan, J

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