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The investigators first determined the presence of GLP-1R in mature oligodendrocyte cells in the CNS

doi: 10.1159/000264392 120 RitterRC

The challenge for oral GLP-1s will not just be meeting demand from existing interest groups, but expanding awareness to the much larger population who still know very little about these treatments

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This requirement of ECL1 recognition drives the above six key positions in dual or triple agonists (tirzepatide, peptide 20 (MAR423), and retatrutide) to use amino acids similar to those in GLP-1/GCG, while the other positions in the middle region show considerable variability (Fig

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