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Description
Patients often report that hunger and cravings return with notable intensity, which can be psychologically challenging

Effects of somatostatin on human satiety
[DOI] [PubMed] [Google Scholar] 863.Pereira M., Gohin S., Roux J.P., Fisher A., Cleasby M.E., Mabilleau G

Furthermore, we provide an overview on GLP-1 RAs and the risk of coronary events

The optimized analog, compound 32 ((4S,5S)-5-(aminomethyl)-1-(2-(benzo[d] [1,3] dioxol-5-yl) ethyl)-4-(2,5-difluorophenyl) piperidin-2-one), was found to exhibit high levels of DPP-4 selectivity and potency in vitro
Around the same time, I think you remember that all of pharma was interested in obesity in the early 90s, everyone wanted to do diabetes as well as obesity, but they were separate teams and they all wanted to do small molecules, but it just happens to be so that the best idea we could find at that time was actually GLP-1, because we actually had clinical data relatively early that GLP-1 was a really good candidate as a treatment for diabetes because of the glucose sensitivity of the actions
