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This editorial and meta-analysis in the BMJ lay out how patients seem to regain weight even faster after stopping GLP-1s than after quitting traditional diets

However, the short half-life and dose-limited adverse gastrointestinal effects of GLP-1 have limited its clinical application

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When compared with LDN, GLP-1 agonists present a distinct mechanism of action with potential synergistic effects onhealthspan extension

10.1210/en.2010-0289 [DOI] [PMC free article] [PubMed] [Google Scholar] Baraboi, E