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While treatment with a particular inhibitor of miR-7 dramatically enhanced cAMP synthesis, miR-7 had a substantial negative effect on GLP-1-induced cAMP levels [167]

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[DOI] [PubMed] [Google Scholar] 79.Buse JB, Nauck M, Forst T, Sheu WH, Shenouda SK, Heilmann CR, et al

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Experimental design Effect of serotonin depletion on weight-loss impact of GLP-1R activation To assess the impact of serotonin depletion on the weight-loss effect of GLP-1R activation, serotonin depleted rats were injected with EX4 and their body weight was followed for five consecutive days of central EX4 injections