history of glp-1 agonists A timeline of GLP- 1 discovery and clinical development. Created in Discovery of GLP-1–Based Drugs for

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Over the past two years, searches for "GLP-1" have surpassed those for "Ozempic," signaling a major shift in public awareness

Although evidence from clinical trials has shown GLP-1 RAs to be safe and efficacious in people living with T2DM and renal impairment, their use is uncommon in this patient population

Retatrutide pharmacokinetics: approximately 6-day half-life per NEJM 2023, 30-day full clearance, and 4-5 week steady state

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