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Differential gene expression of myocytes from semaglutide-treated animals highlighted a broad increase in metabolism, including BCAA catabolism, fatty acid metabolism, the tricarboxylic acid (TCA) cycle, and glycolysis ( Figure 3C )

Semaglutide is FDA-approved and widely available

Specifically, GLP-1R engagement may alleviate endoplasmic reticulum (ER) stress, suppress microglial overactivation, and attenuate the release of pro-inflammatory cytokines and hippocampal neuronal apoptosis

Here are some strategies dietitians can put into practice when counseling patients

Mann is a diplomate of the American Board of Obesity Medicine and a certified menopause practitioner (MSCP) through The Menopause Society