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The most important things to remember are: Consult your provider before starting any new medication to avoid interactions
Call your doctor to discuss all the medicines you are taking before starting any weight loss medication

They have been studied extensively

TABLE 2 Overview of ongoing tirzepatide clinical trials for cardiovascular and metabolic conditions
GLP-1R activation in the hippocampus has been associated with neuroprotective effects and modulation of cognitive functions, which may indirectly affect reward-related behaviors [29]

Increased risks for GI adverse events were found for tirzepatide (HR = 1.53
