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These findings underscore the need for monitoring as GLP-1 use expands, though overall patient risk remains low

Variants in genes such as GLP1R (rs6923761), GIPR (rs1800437), and FTO (rs9939609) affect how efficiently your cells bind and respond to these medications, potentially determining whether you'll need higher or lower doses

Clinical trials demonstrate that semaglutide reduces body weight by 5% to 15% depending on dose and individual response

Through this mechanism, GLP-1RAs may reduce endothelial dysfunction and oxidative stress, both of which are key contributors to sepsis pathophysiology (57)

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These conditions may require hospitalization and/or surgery depending on the severity, according to the researchers