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Why are humanized mouse models important in GLP-1 research

Up to 85% are off GLPs after 2 years Almost all the weight is regained after stopping GLPs GLP-1s can be useful in training for lifestyle change GLP-1s have an upper limit of effectiveness that may not work for 40+ BMI patients Medication and surgery can work symbiotically Any treatment that ensures weight loss and resolution of co morbidities safely is a good thing With the advent of weight loss-approved GLP-1 drugs like Wegovy and Zepbound, there is renewed hope in the fight against excess weight and obesity

placebo of 0.89, 95%CI 0.820.98) (Sattar et al., 2021)

Adachi, Y

Glucagon and type 2 diabetes: the return of the alpha cell

The similar phenotypes shown between total and adipose-tissue-specific Tph1 -KO probably indicates the synthesis of serotonin by TPH1 in adipose tissue in situ , which plays an indispensable role in host metabolism (Fig