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"Oftentimes, patients will say that seeing that kind of image is what not only motivates them to lose weight, but can also be what tells them that their body has started to change as they lose the weight," he says

Diabetes in India [Internet]

This effect is relevant for women using oral contraceptives

Jeek P, Holendov B, Jabrek M, et al

Optimizing dosing schedules and administration routes is critical to maximize therapeutic efficacy while minimizing adverse effects such as hypoglycemia and gastrointestinal intolerance

They should not be used by: People with a history of pancreatitis (inflammation of the pancreas) Anyone with a personal or family history of medullary thyroid cancer (a rare type of thyroid cancer) People with multiple endocrine neoplasia type 2 (MEN 2, a rare inherited condition that raises the risk of certain hormone-related tumors, including thyroid cancer) Women who are pregnant or breastfeeding People with severe stomach or bowel problems, such as gastroparesis (slow stomach emptying that causes nausea, fullness, or vomiting) or inflammatory bowel disease (chronic inflammation of the digestive tract, such as Crohns disease or ulcerative colitis) Those with severe kidney problems, especially with certain types of GLP-1 medicines, such as exenatide Anyone with allergies to GLP-1 medications or who has had a severe reaction to them Use in children is limited to certain GLP-1 medicines approved for adolescents with obesity