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The first 48 weeks are typically when side effects peak , nausea, constipation, low energy, and the steepest drop in appetite as your dose escalates

Phase 3 trials are currently underway (see ClinicalTrials.gov for current listings)

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Nonsteroidal MRAs (nsMRA) supposedly selectively block this pathway, suppressing pro-inflammatory and pro-fibrotic signaling and slow structural kidney damage beyond their modest hemodynamic effects

doi: 10.1053/j.gastro.2004.04.063 35 PocaiA

However, these compounded versions havent undergone rigorous clinical testing to confirm their absorption or safety