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On current evidence, effective weight management should be provided to all people with type 2 diabetes as soon as possible after diagnosis (or even earlier, at the stage of prediabetes, defined in Europe, Australasia, Canada [and most of the world] as 42 and 10 kg and remission lasting 12 years may also delay vascular complications, although more evidence is needed

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When these internal systems are not functioning properly, maintaining a healthy weight can become extremely difficult even with a strict lifestyle routine

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Although the excessive use of certain performance-enhancing drug (PED) classes is associated with clear health risks, current evidence on PED-related cardiovascular (CV) risk is primarily derived from retrospective reports, small cohorts, or illicit use, leaving major gaps in mechanistic understanding and doseresponse relationships in performance enhancement, well-being, and rehabilitation purposes

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