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Nicotinamide phosphoribosyltransferase (NAMPT)-mediated nicotinamide adenine dinucleotide (NAD + ) biosynthesis in major metabolic organs such as the liver, adipose tissue, and skeletal muscle plays a crucial role in obesity- and aging-associated organ derangements

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31 In addition, studies examining the electrophysiological properties of hypothalamic neurons upon GLP-1 receptor activation also applied 100 nM Ex-4 32 or the effective submaximal dose of 1 M Ex-4, a concentration that is 10-fold greater than we used in our experiments

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