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2007, Pujadas et al

The expression levels of IL-6, IKK- and NF-B were elevated in pancreatic cells from T2DM rats, accompanied by increased Bax expression and decreased Bcl-2 expression, as well as decreased pancreatic -cell function

In contrast to the majority of anti-diabetic compounds, DPP-4 inhibitors do not produce weight gain as a side effect, which is crucial for limiting body weight gain during long-term therapy for diabetes

Scientific studies suggest that berberine may indirectly activate GLP-1 receptors, thereby aiding in appetite control and improving insulin sensitivity

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Global prevalence of sarcopenic obesity in older adults: A systematic review and meta-analysis