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First, the 2.5 mg starting dose is not therapeutic

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The left colon particularly the watershed areas at Griffiths point (splenic flexure) and Sudecks point (rectosigmoid junction) is disproportionately affected due to its tenuous blood supply at the margins of the superior and inferior mesenteric arterial territories

By the time symptoms appear, you are already significantly dehydrated

Obesity is believed to be one of the major modifiable risk factors for T2DM (Zhou et al., 2023)

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