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Semaglutide exhibits superior hypothalamic activity, leading to greater feelings of fullness and a more drastic reduction in calorie intake [9]

Important Notes Practical points that keep microgram-scale administration consistent and reduce avoidable harm

Similar results have been obtained following treatment with tirzepatide, and there is increasing evidence that decreased appetite and disinterest in high-calorie foods, particularly those high in fat,represents a common mode of action for both molecules

Once pharmacological treatment is initiated and proves effective, it should not be arbitrarily time-limitedjust as we would not discontinue treatment for diabetes, hypertension, or other chronic diseases

Starting with a lower semaglutide dose and increasing gradually over 48 weeks allows the body to adapt to appetite suppression and reduced meal sizes, which also helps mitigate nausea

The double-blind study involved 9,650 participants across 33 countries recruited between 2019 and 2021 and followed for almost 4 years on average