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The drug, which was originally developed at Karuna Therapeutics, began its development journey as an investigational treatment at Eli Lilly for Alzheimers disease, where its effects on the psychotic symptoms of the disease where discovered

Rossing P, Anker SD, Filippatos G, Pitt B, Ruilope LM, Birkenfeld AL, McGill JB, Rosas SE, Joseph A, Gebel M, et al

MIN6B1 were treated as INS-1 832/3 but in Krebs-HEPES-bicarbonate (KHB) buffer (140 mM NaCl, 3.6 mM KCl, 1.5 mM CaCl 2 , 0.5 mM MgSO 4 , 0.5 mM NaH 2 PO 4 , 2 mM NaHCO 3 , 10 mM HEPES, and 1% BSA

While this is beneficial, it also means that existing medications such as insulin or sulfonylureas may become too potent
