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12 In particular, the analysis focused on patients with MASH F3, as this subgroup is well represented in the ESSENCE trial population, represents the majority of obese patients with MASH, and corresponds to a clinically meaningful stage where early intervention may prevent progression to more advanced liver disease and its associated burden

The drug had a half-life of about one week and stronger effects on glycaemia and body weight with mean reductions in HbA 1c of 18 mmol/mol and in body weight of 5.7 kg in the phase-III programme [20]

The weight-reducing and appetite-suppressing effects of GLP-1RAs may also offer an important tool for managing IIH patients who struggle with weight loss through lifestyle changes alone (1)

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