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Raufman J-P, Singh L, Singh G, Eng J (1992) Truncated glucagon-like peptide-1 interacts with exendin receptors on disperced acini from guinea pig pancreas

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Common gastrointestinal side effects include: Nausea and vomiting : Usually most pronounced during initial treatment and dose escalation, often improving over 48 weeks Diarrhoea or constipation : Can affect hydration and nutritional status Abdominal discomfort : Typically mild and transient Patients can manage mild gastrointestinal symptoms by eating smaller, more frequent meals, avoiding high-fat foods, staying well-hydrated, and taking the medication as directed