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Parallel fibrogenesis in the liver and myocardium adds to ventricular stiffness and diastolic dysfunction, while gut dysbiosis from a Western diet heightens systemic inflammation and endotoxemia, worsening cardiac and hepatic dysfunction

One of the biggest questions surrounding GLP-1 research in osteoarthritis is whether the observed improvements simply reflect reduced body weight

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Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity

or already taking another GLP-1 medicine