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These medications, primarily prescribed for type 2 diabetes and weight loss, are now at the center of thousands of claims alleging severe gastrointestinal injuries

Its premise is an upstream intervention targeting substantial weight reduction to improve key risk factors with the aim to avoid potential downstream complications from multiple co-morbidities, e.g., hypertension, dyslipidaemia, heart failure, kidney disease, NAFLD/NASH or diabetes

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GLP-1 receptor agonists and hormonal birth control can be used together safely in most cases, though gastrointestinal effects may reduce oral contraceptive absorption in rare instances