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These neurons integrate peripheral metabolic cues via vagal afferents and project directly to the VTA and NAc, where GLP-1R activation decreases food intake and body weight, particularly suppressing consumption of highly palatable foods [12,21]

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Sources: Novo press release, cms.gov, Institute for Clinical and Economic Review, ro.com

Those who used GLP-1 agonists had a 14% lower risk of developing cirrhosis, a 22% lower risk of cirrhosis complications (decompensation, liver cancer or liver transplant) and an 11% lower risk of death from any cause

Secondary outcomes included the effect of retatrutide treatment at week 48 compared with placebo for relative liver fat change, absolute liver fat change at weeks 24 and 48, and the percentage of participants achieving a 30% or greater relative liver fat reduction

While it is effective, some people report heart palpitations while taking it