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In the intracellular side, a sharp kink located in the conserved Pro 6.47b -X-X-Gly 6.50b motif pivoted the intracellular tip of TM6 to move outwards by 19.3 (measured by C atom of K344 6.35b ), slightly higher than that seen with the GCGGCGRG s (17.7 ) 4

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Newly-discovered brain nuclei related to leptin function Recently, multiple studies identified a series of clusters of neurons expressing LepR in certain nuclei as novel mediators involved in metabolic regulation

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Screening for diabetic kidney disease Early-stage DKD is usually a silent disease, with minimal clinical manifestations until the patient has progressed to an advanced stage of kidney disease

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