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doi: 10.1111/jdi.12861

Additionally, GLP-1RAs were able to address the pathophysiology of T2DM through an indirect mechanism also

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The triple-agonist mechanism, particularly the glucagon component driving preferential fat oxidation, appears to shift the ratio toward greater fat selectivity

Other observational studies have linked GLP-1 drugs to lower rates of new and recurring alcohol use disorder, reduced diagnoses and relapse in cannabis use disorder, fewer health care visits for nicotine dependence and lower risk of opioid overdose