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Mechanistically, GLP-1 receptor agonists influence inflammatory signaling pathways

Patient outcomes following AKI and AKD: a population-based cohort study
The activated receptor also recruits beta-arrestins, which dampen G protein signaling and draw the receptor inside the cell, a process that controls how long and how strongly the receptor fires
Most GLP-1 medications do not require dose adjustment in mild to moderate renal or hepatic impairment

OKeefe JH, Franco WG, OKeefe EL
