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What the clinical trial evidence shows Mounjaro (tirzepatide) ~22.5% average body weight lost at 72 weeks ( SURMOUNT-1, 15mg) Wegovy (semaglutide) ~14.9% average body weight lost at 68 weeks ( STEP-1 , 2.4mg) Saxenda / Nevolat (liraglutide) ~5-8% average body weight lost at 56 weeks ( SCALE trial ) For context, prior to GLP-1 medications, the most effective non-surgical weight loss intervention available was a combination of intensive lifestyle modification and Orlistat , which typically produces 5 to 8% weight loss

Click here to listen to this article Share via Key Facts The Rule of 20-30%: In typical weight loss, approximately 20-30% of mass lost is lean tissue (muscle/bone/water), not just fat

Patients considering treatment can also understand who is eligible for weight loss injections in the UK before starting long-term weight management support

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