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As previously mentioned, because DPP-4 inhibitors can increase the risk of hypoglycemia when added to insulin or a sulfonylurea, a dose decrease of sulfonylurea and/or insulin should be considered prior to initiation of a DPP-4 inhibitor

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Makers of snack foods should take steps now to understand how these changes will affect their businesses, and consider reshaping their product portfolios to maintain future competitiveness

Key safety observations from available trial data include: Elevated resting heart rate in a dose-dependent manner Gastrointestinal adverse effects (nausea, vomiting, diarrhoea) as the most common side effects, consistent with the GLP-1 receptor agonist class [1] [3] No clinically significant QT interval prolongation was reported in available data, though the extent of formal thorough QT assessment has not been fully detailed in published sources

Open Access ARTICLE Early GLP-1 Agonist Use and Cancer Risk in Type 2 Diabetes: A Real-World Data Cohort Study 1 Institute of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan 2 Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan 3 Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung, 402, Taiwan 4 Department of Internal Medicine, Zuoying Armed Forces General Hospital, Kaohsiung, 813, Taiwan 5 Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, 114, Taiwan 6 Graduate Institute of Aerospace and Undersea Medicine, College of Biomedical Sciences, National Defense Medical University, Taipei, 114, Taiwan 7 Department of Orthopedic Surgery, Chung Shan Medical University Hospital, Taichung, 402, Taiwan 8 School of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan 9 Department of Medical Research, Chung Shan Medical University Hospital, Taichung, 402, Taiwan * Corresponding Authors: Yu-Hsun Wang
