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Commonly reported retatrutide side effects in trials include: Nausea (especially during dose increases) Vomiting Diarrhoea or constipation Abdominal pain or bloating Indigestion / reflux Injection-site reactions or hypersensitivity in some people So far, hair loss has not been listed as a common, direct side effect of retatrutide in clinical trial publications

Existing weight-loss drugs such as Wegovy, commonly referred to a GLP-1s, mimic the effects of glucagon-like peptide-1, a hormone that regulates metabolism

Besides, GLP-1RA NLY01 could significantly reduce the proportion of infiltrating white blood cells (CD45 high ) and monocytes (Clec12a + ) in the central nervous system (CNS), while decreasing the number of effector/memory T cells (CD4 + CD44 + ) and inhibiting inflammation in peripheral circulation and CNS (90)

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Researchers also acknowledged the need for more research that could include a larger, randomized sample group for a longer period

Dosing Comparison# Retatrutide Dosing# Based on Phase 2 clinical trial protocols (investigational only): Starting dose : 0.5 mg weekly subcutaneous injection Escalation : Gradual increase over 12-24 weeks to target dose (up to 12 mg) Target doses tested : 1, 4, 8, and 12 mg weekly Escalation rationale : Extended 24-week escalation for higher doses reduces GI side effects compared to faster 12-week escalation No commercial formulation exists