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Lipid profile GLP-1RAs exert anti-inflammatory effects in the CV system, reduce hepatic steatosis, and lower circulating triacylglycerol and low-density lipoprotein (LDL) cholesterol levels

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Moreover, elevated cortisol levels impair neurogenesis in the hippocampus, a brain region involved in both depression and T2DM [74]

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Based on data from Phase 2 clinical trials published in the New England Journal of Medicine (2023), retatrutide is administered as a once-weekly subcutaneous injection , typically into the abdomen, thigh, or upper arm