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At 12 mg, TRIUMPH-4 also saw more dysesthesia (skin tingling/ numbness, 20.9% vs 8.8% at 9 mg) and more discontinuations for side effects (18.2% vs 12.2%) the extra ~2.3 points of weight loss over 9 mg is a tolerability trade-off

The first modification is the replacement of alanine at position 8 with -amino isobutyric acid, which helps prevent degradation by DPP-4

These peptides are often discussed together because they both support the bodys natural growth hormone pathway, but they are not the same thing
Remove the cap covering the needle, and set it on its side to keep it clean

Georgescu EF, Ionescu R, Niculescu M, et al

Physiology & Behavior, 136, 4754
