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As more people take the drug, the number of people experiencing severe side effects will also increase

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Since gastric distension (both of the proximal and distal stomach) can lead to reduced food/energy intake (64, 65), the question arises as to whether the slowing of gastric emptying, via increased gastric distension, contributes to the regulation of appetite and energy intake

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Moreover, because adverse effects are more prevalent at higher GLP-1 RA doses, discontinuation of these medications might lead to a high likelihood of side-effects upon medication reinitiation or require reinitiation of therapy at lower doses followed by dose reescalation

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FEEL THE DIFFERENCE IN DAYS, NOT WEEKS Day 13: Magnesium begins softening stool and improving motility

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doi:10.3945/ajcn.2009.28449C 10

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Cardiovascular protection Randomised controlled cardiovascular outcome trials (CVOTs) have shown that liraglutide, dulaglutide and semaglutide reduce major adverse cardiovascular events (MACE

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