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Targeting ATR in cancer

2026 ( Clinical Obesity ), 480,825 adults: vitamin D deficiency 13.6% at 12 months, iron depletion 2630% lower ferritin, rising B vitamin deficiency

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Identifying small-molecule agonists for class B1 GPCRs such as GLP-1R remains challenging due to the receptors conformational plasticity and its large, peptide-optimized binding interface (Liu et al., 2025)