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Semaglutide is the proven GLP-1 agonist that established the modern obesity pharmacotherapy era
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Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 10, 314-323

Graphical abstract Suspected clinical impacts of GLP-1RAs, SGLT2is, and finerenone oncardiovascular and kidney outcomes

some clinicians also prescribe it off-label for weight loss

While there are some indirect pathways that cause the secretion of the hormone, the direct exposure of L cells to content within the tract appears to be the primary route for GLP-1 stimulation