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Patients currently using any GLP 1 medication should consult their healthcare provider before making changes as switching between products requires careful dose conversion and monitoring

Reflecting this difficulty Novartis and Probiodrug had to abandon some of their early drug candidates because they proved unsafe and too toxic (Cordes)

On average, they suffered from type 2 diabetes for 12 years, but this varied greatly among participants

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Acknowledgements This study was performed with the support of the National Natural Science Foundation of China (82002339, 81820108020), Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System (BJ1-9000-22-4002)