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doi: 10.3389/fendo.2026.1758848 Received 02 December 2025 Revised 19 January 2026 Accepted 21 January 2026 Published 09 February 2026 Volume 17 - 2026 Edited by Antonio Rossi, University of Milan, Italy Reviewed by Juraj Stanik, Comenius University, Slovakia Kishore Shil, Khulna Medical College Hospital, Bangladesh Updates Copyright 2026 Dikranian, Hadara and Lysy

If your serotonin system is already dysregulated, the additional modulation could create temporary instability

Cagrilintide is a long-acting amylin analogue, whilst retatrutide is a novel triple receptor agonist targeting GLP-1, GIP, and glucagon pathways

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and 3, 7 and 14 mg oral) or comparator (placebo, sitagliptin, exenatide extended release, insulin glargine, dulaglutide, liraglutide and empagliflozin)