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5.Price Comparison (Global) Approximate US therapy cost: Drug:Annual cost Semaglutide:~$22,800 Tirzepatide:~$17,500 Cost per % weight reduction is lower with tirzepatide, making it more cost-effective in some analyses

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Fierce Healthcare article, 9 May 2023: [12] Thomas CE, Mauer EA, Shukla AP, Rathi S, Aronne LJ

In a US societal-perspective lifetime simulation based on SURMOUNT-5 data, tirzepatide was projected to deliver lower total costs and better health outcomes than semaglutide for adults with obesity or overweight without type 2 diabetes.