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All GLP-1RAs retain the capacity to activate the GLP-1 receptor (GLP-1R), thereby initiating intracellular signaling cascadesincluding cAMP accumulation, protein kinase A (PKA) activation, and PI3K/Akt pathway engagementunderlying their endocrine, metabolic, and neuroprotective effects [8]

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Cold water, herbal teas, and low-sugar electrolyte beverages (no artificial sweeteners if possible, as they may worsen GI sensitivity) all count toward daily fluid intake

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