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Baseline markers may include: Fasting glucose HbA1c Lipid panels Body composition measurements when available Without baseline measurements, it becomes difficult to determine whether metabolic changes are occurring or whether dose adjustments are producing meaningful effects

Distinct alterations of hypothalamic proteomic profiles by GLP1/E in lean and obese PCOS mice Finally, considering that the hypothalamus is likely the primary target of the GLP1/E conjugate, we assessed changes in global hypothalamic proteome in PWA and PNA mice following GLP1/E treatment, using cutting-edge liquid chromatographytandem mass spectrometry (LC-MS/MS)

doi: 10.2337/dbi18-0045 5 HeSKahlesFRattikSNairzMMcAlpineCSAnzaiAet al

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Different bodies have different needs and differences in hormonal activity, as well as microbiome diversity

Previous reviews of clinical trials evaluated the effect of the SGLT-2i and GLP-1RA combination on metabolic factors, and they showed a mostly positive effect [65, 66]