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GLP-1 Receptor (GLP-1R) Agonism Stimulates glucose-dependent insulin secretion: Enhances pancreatic beta-cell insulin release, thus lowering blood glucose 1,3,4

doi: 10.1007/s00192-024-06029-2

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DISCUSSION In patients with T2D, MBS provides better long-term glycemic control than conventional treatment, with reductions in diabetes medication use [13,32]

GLP-1 has an impact on various biological mechanisms, including improved insulin sensitivity, inhibition of glucagon synthesis, slowing gastric emptying [19], and reduced pancreatic cell apoptosis, when it signals through its specialized G protein-coupled receptor (GPCR), GLP-1R [20]