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However, there are some common indicators that it might be time to consider maintenance doses

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For example, Lilly is studying orforglipron, a daily oral non-peptide GLP-1 agonist which is easier and less costly to manufacture vs

Retatrutide is an investigational triple agonist medicine that simultaneously activates glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

This framework helps providers assess whether dosing adjustments are needed and when to recheck thyroid function
