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Once your dose is set, prime the pen by holding it with the needle pointing up and pressing the administration button until a drop of the solution appears at the tip

Sjstrm L, Rissanen A, Andersen T et al (1998) Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients

User reports suggest effects may appear at lower doses than required for maximum weight loss

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