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In chronic kidney disease, the pivotal FLOW trial demonstrated that semaglutide 1 mg reduced the risk of major kidney events by 24% in patients with type 2 diabetes and CKD, resulting in a dedicated indication in this population

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Generally, fasting insulin and the total insulin output in response to intravenous glucose are reduced after bariatric surgery 55 , a pattern consistent with enhanced insulin sensitivity occurring in response to postoperative weight loss

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Patients should maintain adequate fluid intake and seek medical advice if unable to stay hydrated

New receptor targets, multi-hormone combinations, and drugs engineered at a molecular level to hit the metabolic system from multiple angles simultaneously are moving through the pipeline faster than public conversation can catch them