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Direct cortisol-lowering is not semaglutide's primary mechanism, but clinical observations suggest GLP-1 activation may normalize cortisol's diurnal rhythm and reduce stress-induced cortisol spikes

Tirzepatide (Zepbound) uses Eli Lilly's KwikPen auto-injector: a prefilled once-weekly pen delivering subcutaneous injection into the abdomen, thigh, or upper arm, with four doses per pen

Medications prescribed through a telehealth service generally come with a vial and syringes to draw the drug out at home

The use of polygenic risk scores (PRSs), which summarize the effect of multiple common genetic risk variants across the genome, has further contributed to our understanding of the genetic relationship between MDD and T2DM

Moreover, the insulinotropic potency of GIP is markedly reduced in non-diabetic, first-degree relatives of T2D patients (54), suggesting altered GIP signaling could be one of the many predisposing factors for T2D later in life

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