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However, those same models confirm that GLP-1 RA did not significantly raise testosterone in the obese animalsmdpi.com, indicating that weight loss or additional interventions might be needed to normalize androgens

306 A recent study found that the insulin response to intravenous glucagon was preserved in GLP-1 receptor knockout mice but that glucagons insulinotropic actions were suppressed in isolated islets from GLP-1 receptor knockout mice

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It has been shown that exendin-4 enhanced the proliferation and differentiation of osteoblasts partly mediated by MAPK pathways, including ERK1/2, p38, and JNK pathways (48)