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Although GLP-1RAs have shown remarkable efficacy in weight management, several barriers limit their full integration into mainstream obesity care

In many case reports, the use of these drugs, mainly exenatide, has been associated with acute kidney injury, in which hemodynamic factors are predominantly implicated

Higher HbA1c has also been consistently associated with cardiovascular disease risk, worse cognitive aging, increased liver fat, early kidney impairment, higher inflammation, reduced fertility, and higher mortality risk

Distribution Channel Analysis The hospital pharmacies segment grew at a substantial rate, generating a revenue portion of 57.8% as hospitals are key centers for the diagnosis and management of type 2 diabetes and obesity, often initiating treatment with GLP-1 receptor agonists

The most commonly reported side effects of medications used for weight loss are nausea and constipation, but gallbladder and pancreatic disease are also reported

25 , 26 In head-to-head RCTs, GLP-1 RAs that induce greater weight loss are also associated with larger BP reductions, 27 , 28 supporting a meaningful contribution of weight-mediated mechanisms to their antihypertensive effect