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CVOTs have become a cornerstone in evaluating antidiabetic medications, mandated by regulatory agencies to ensure that these drugs do not exacerbate cardiovascular risk

Christel, C

Plaintiffs argued that other diagnostic methods should be accepted

What Berberine Research Does NOT Demonstrate Responsible evaluation of berberine requires acknowledging the boundaries of current evidence : Research has not established berberine as a substitute for prescription medications Weight outcomes vary significantly among individuals Effects observed in study conditions may not replicate in all real-world scenarios Transdermal delivery of berberine specifically requires additional research Most clinical studies examined oral berberine