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Research indicates that GLP-1s may have beneficial effects in those with knee osteoarthritis, including reduced pain and fewer joint replacements by reducing weight and inflammation

From week 8 to end of treatment, the daily caloric target was calculated based on body weight at randomization

Clinical Pharmacokinetics 60: 1335-1348

If you normally inject on Tuesdays but need to move to Wednesday one week, that single shift is unlikely to affect your results
