incretin hormone glp-1 hormones and obesity - Alcaino - 2025 - The Journal of Physiology Biology of Incretins: GLP-1 and

Description

This study aimed to clarify the association between GLP-1 RA use and GI cancer risk

These drugs also have low uptake (less than 2% in the USA) due to several factors, including patients reluctance to seek treatment, lack of addiction training among healthcare providers and considerable stigma surrounding AUD and addiction. - Lorenzo Leggio, et al, Nature Medicine, December 2023 Based on the percentage of people in the United States with alcohol use disorder (11% or ~29.5 million) and the number of people who have received medication for alcohol use disorder in the past year (624,000) and the number of people taking GLP-1 drugs (7 percent of American adults or 18 million), we roughly estimate that more than 3 times as many people with AUD have been incidentally prescribed a GLP-1 in the past year than have been prescribed a medication that is FDA indicated for alcohol use disorder (~2 million vs 624,000, and these groups may overlap)

Orforglipron 3 mg, 12 mg, and 36 mg Tablets are not yet licensed, approved, or available to the public in the UK

Our studies show that GLP-1 receptor agonists strongly activate the hypothalamic pituitary adrenal (HPA) axis the system that produces stress hormones such as cortisol in humans and corticosterone in preclinical models