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Sleep deprivation alters ghrelin and leptin levels (hormones that regulate appetite and digestion), increases cortisol production, and disrupts the circadian rhythm of your gut bacteria

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doi:10.1042/BSR20181061 175

Although the use of glucagon alone may not be favorable for weight management, combining it with other gut-pancreatic hormones (such as GLP-1) might represent a new direction in the development of drugs for obesity, aiming to balance blood sugar regulation with weight reduction